Which cells are the most radiosensitive in the hematopoietic system?

Lymphocytes are the most radiosensitive cell type in the hematopoietic system. This sensitivity to radiation is primarily due to their high mitotic activity and the fact that they are part of the immune response, which requires continual production and turnover. Lymphocytes, especially B and T cells, have a significant role in the body's defense mechanisms and are produced in the bone marrow and thymus.

When exposed to ionizing radiation, these cells can suffer from DNA damage, leading to impaired immune function. The consequences of lymphocyte depletion are particularly noticeable in individuals who undergo radiation therapy or are exposed to high doses of radiation, highlighting the critical role these cells play in maintaining overall health and immune system function.

In contrast, granulocytes, erythrocytes, and platelets are more resistant to radiation compared to lymphocytes. Granulocytes, although they are also part of the immune response, have a shorter lifespan and are produced in larger numbers, which somewhat mitigates the effects of radiation. Erythrocytes, or red blood cells, are not directly involved in the immune response and are more resilient to radiation damage. Platelets, which play a role in blood clotting, are derived from megakaryocytes and have