Which organ shows a significant response to high doses of radiation with a threshold effect?

The skin is known to exhibit a significant response to high doses of radiation, characterized by a threshold effect. A threshold effect means that there is a specific dose level of radiation below which no observable effects occur, but above this level, the severity of the effects tends to increase with dose. When the skin is exposed to high levels of radiation, it can develop conditions such as erythema (redness), desquamation (peeling), and in severe cases, radiation burns or ulcers.

The skin is a highly radiosensitive organ because it contains rapidly dividing cells in its outer layers. The threshold for skin effects may vary among individuals but typically becomes evident only after a certain level of cumulative radiation exposure has been reached. This contrasts with other organs such as the heart, lungs, and liver, which may have more complex responses to radiation exposure and may not demonstrate a clear threshold effect in the same sense as the skin does.